| Applications: | IF, WB |
| Species Reactivity: | Human, Rat |
| Isotype: | IgG2b |
| Purification: | Mouse Monoclonal Antibody |
| Description: | Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. |
| Further Information: | Purified His-tagged SUMO2 protein was used to produced this monoclonal antibody. |
| Synonym: | Small ubiquitin-related modifier 2, SUMO-2, HSMT3, SMT3 homolog 2 {ECO:0000312|HGNC:HGNC:11125}, SUMO-3, Sentrin-2, Ubiquitin-like protein SMT3B, Smt3B, SUMO2 (<a href=http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=11125 target=_blank>HGNC:11125</a>) |
| Ascension Number: | P61956 |
| NCBI EntrezGene: | 6613 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
