Ordering Details
Cat Number:	AM2220b
Size:	400uL
Price:	£304.00
Quantity:
Shipping:	£12.00

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Data Sheet

MSDS

USP14 [N-term] [889CT6.2.1], Mouse Monoclonal Antibody

Partner: Abcepta, Inc.

Applications:	WB
Species Reactivity:	Human, Mouse, Rat
Isotype:	IgG1
Purification:	Mouse Monoclonal Antibody
Description:	Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).
Further Information:	Purified His-tagged USP14 protein was used to produced this monoclonal antibody.
Synonym:	Ubiquitin carboxyl-terminal hydrolase 14, Deubiquitinating enzyme 14, Ubiquitin thioesterase 14, Ubiquitin-specific-processing protease 14, USP14, TGT
Ascension Number:	P54578
NCBI EntrezGene:	9097
Shipping Conditions:	Ship on cold packs
Storage:	Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles.
Usage:	Research use only

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USP14 Antibody (N-term)(Cat. #AM2220b) western blot analysis in k562,Jurkat cell line ,mouse brain and rat brain tissue lysates (35?g/lane).This demonstrates the USP14 antibody detected the USP14 protein (arrow).