Ordering Details
Cat Number:	AM2212B-ev
Size:	80uL
Price:	£117.00
Quantity:
Shipping:	£12.00

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Data Sheet

MSDS

PIN1 [855CT1.7.5], Mouse Monoclonal Antibody

Partner: Abcepta, Inc.

Applications:	WB, IHC-P
Species Reactivity:	Human, Mouse, Rat, African Green Monkey
Isotype:	IgG1
Purification:	Mouse Monoclonal Antibody
Description:	Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.
Further Information:	Purified His-tagged PIN1 protein was used to produced this monoclonal antibody.
Synonym:	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Peptidyl-prolyl cis-trans isomerase Pin1, PPIase Pin1, Rotamase Pin1, PIN1
Ascension Number:	Q13526
NCBI EntrezGene:	5300
Shipping Conditions:	Ship on cold packs
Storage:	Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles.
Usage:	Research use only

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PIN1 Antibody (Cat. #AM2212b) western blot analysis in Hela,293,mouse NIH/3T3,PC-12,COS-7 cell line and mouse brain,rat brain tissue lysates (35?g/lane).This demonstrates the PIN1 antibody detected the PIN1 protein (arrow).