| Applications: | WB |
| Species Reactivity: | Human |
| Isotype: | IgM |
| Purification: | Mouse Monoclonal Antibody |
| Description: | This intronless gene encodes the receptor protein formelanocyte-stimulating hormone (MSH). The encoded protein, a sevenpass transmembrane G protein coupled receptor, controlsmelanogenesis. Two types of melanin exist: red pheomelanin andblack eumelanin. Gene mutations that lead to a loss in function areassociated with increased pheomelanin production, which leads tolighter skin and hair color. Eumelanin is photoprotective butpheomelanin may contribute to UV-induced skin damage by generatingfree radicals upon UV radiation. Binding of MSH to its receptoractivates the receptor and stimulates eumelanin synthesis. Thisreceptor is a major determining factor in sun sensitivity and is agenetic risk factor for melanoma and non-melanoma skin cancer. Over30 variant alleles have been identified which correlate with skinand hair color, providing evidence that this gene is an importantcomponent in determining normal human pigment variation. [providedby RefSeq]. |
| Further Information: | This MC1R antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 205-232 amino acids from the Central region of human MC1R. |
| Synonym: | Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R, MC1R, MSHR |
| Ascension Number: | Q01726 |
| NCBI EntrezGene: | 4157 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
