| Applications: | WB |
| Species Reactivity: | Human |
| Isotype: | IgG2b |
| Purification: | Mouse Monoclonal Antibody |
| Description: | The protein encoded by this gene belongs to the BCL2protein family. BCL2 family members form hetero- or homodimers andact as anti- or pro-apoptotic regulators that are involved in awide variety of cellular activities. This protein forms aheterodimer with BCL2, and functions as an apoptotic activator.This protein is reported to interact with, and increase the openingof, the mitochondrial voltage-dependent anion channel (VDAC), whichleads to the loss in membrane potential and the release ofcytochrome c. The expression of this gene is regulated by the tumorsuppressor P53 and has been shown to be involved in P53-mediatedapoptosis. Multiple alternatively spliced transcript variants,which encode different isoforms, have been reported for this gene. |
| Further Information: | This BAX antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 28-56 amino acids from human BAX . |
| Synonym: | Apoptosis regulator BAX, Bcl-2-like protein 4, Bcl2-L-4, BAX, BCL2L4 |
| Ascension Number: | Q07812 |
| NCBI EntrezGene: | 581 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
