| Applications: | WB |
| Species Reactivity: | Human |
| Isotype: | IgG1 |
| Purification: | Mouse Monoclonal Antibody |
| Description: | In mammals, histamine is metabolized by two majorpathways: N(tau)-methylation via histamine N-methyltransferase andoxidative deamination via diamine oxidase. This gene encodes thefirst enzyme which is found in the cytosol and usesS-adenosyl-L-methionine as the methyl donor. In the mammalianbrain, the neurotransmitter activity of histamine is controlled byN(tau)-methylation as diamine oxidase is not found in the centralnervous system. A common genetic polymorphism affects the activitylevels of this gene product in red blood cells. Multiplealternatively spliced transcript variants that encode differentproteins have been found for this gene. |
| Further Information: | Purified His-tagged HNMT protein(Fragment) was used to produced this monoclonal antibody. |
| Synonym: | Histamine N-methyltransferase, HMT, HNMT |
| Ascension Number: | P50135 |
| NCBI EntrezGene: | 3176 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
