| Applications: | IF, WB |
| Species Reactivity: | Human |
| Isotype: | IgG1,k |
| Purification: | Mouse Monoclonal Antibody |
| Description: | Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. |
| Further Information: | This BMI1 monoclonal antibody is generated from mouse immunized with BMI1 recombinant protein. |
| Synonym: | Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, RING finger protein 51, BMI1, PCGF4, RNF51 |
| Ascension Number: | P35226 |
| NCBI EntrezGene: | 100532731;648 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
