| Applications: | WB |
| Species Reactivity: | Human, Mouse |
| Isotype: | IgG1,k |
| Purification: | Mouse Monoclonal Antibody |
| Description: | The protein encoded by this gene is a member of theprotein tyrosine phosphatase (PTP) family. PTPs are known to besignaling molecules that regulate a variety of cellular processesincluding cell growth, differentiation, mitotic cycle, andoncogenic transformation. This PTP contains two tandem Srchomology-2 domains, which function as phospho-tyrosine bindingdomains and mediate the interaction of this PTP with itssubstrates. This PTP is widely expressed in most tissues and playsa regulatory role in various cell signaling events that areimportant for a diversity of cell functions, such as mitogenicactivation, metabolic control, transcription regulation, and cellmigration. Mutations in this gene are a cause of Noonan syndrome aswell as acute myeloid leukemia. |
| Further Information: | This PTPN11 monoclonal antibody is generated from mouse immunized with PTPN11 recombinant protein. |
| Synonym: | Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D, PTP-1D, Protein-tyrosine phosphatase 2C, PTP-2C, SH-PTP2, SHP-2, Shp2, SH-PTP3, PTPN11, PTP2C, SHPTP2 |
| Ascension Number: | Q06124 |
| NCBI EntrezGene: | 5781 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles. |
| Usage: | Research use only |
