| Description: | The MMP-2 protein, a versatile metalloproteinase, actively engages in physiological processes like vasculature remodeling, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. Apart from degrading extracellular matrix proteins, it acts on non-matrix proteins, promoting vasoconstriction. Cleaving KISS and participating in myocardial cell death pathways, it contributes to oxidative stress by regulating GSK3beta. In collaboration with MMP14, it forms fibrovascular tissues. The C-terminal fragment PEX exhibits anti-angiogenic and anti-tumor properties, inhibiting cell migration and adhesion while serving as a ligand for integrin alpha-v/beta3 on blood vessels. MMP-2 Protein, Human (HEK293) is the recombinant human-derived MMP-2 protein, expressed by HEK293, with tag free. The total length of MMP-2 Protein, Human (HEK293) is 631 a.a., with molecular weight of ~72 kDa. |
