Mouse CD8a/Ly-2, PE/Cy5.5, Rat Monoclonal Antibody
Partner: Aviva Systems Biology
| Applications: | FC |
| Isotype: | Rat |
| Immunogen: | Spleen cells or thymocyte membranes |
| Conjugation: | PE/Cy5.5 |
| Description: | In the mouse, CD8 exists in two forms - (i) a CD8 heterodimer composed of an alpha chain (CD8 alpha) and a beta chain (CD8 beta); and (ii) a homodimer of two alpha chains. The heterodimer is found on the surface of essentially all thymocytes and the suppressor/cytotoxic subpopulation of mature T lymphocytes. Subsets of intestinal intraepithelial lymphocytes express CD8 alpha without CD8 beta. It has been suggested that CD8+ beta- T cells mature extrathymically, while development of the CD8 alpha+ beta+ population of T cells is thymus-dependent. CD8 acts as a coreceptor with MHC Class I-restricted T cell receptors in antigen recognition and positive selection of MHC class I-restricted CD8+ T cells. In vivo and in vitro treatment with the 53-6.7 monoclonal antibody effectively depletes CD8 alpha+ cells. The 53-6.7 monoclonal antibody also blocks allogeneic help specific for class I MHC antigens and T cell responses to IL-2. |
| Shipping Conditions: | Ship on cold packs |
| Usage: | Research Use Only |
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