| Applications: | SDS-PAGE |
| Species Reactivity: | Human |
| MW: | 32 kDa (245 aa), confirmed by MALDI-TOF. |
| Purity: | > 95% by SDS - PAGE |
| Description: | The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon, sigma, zeta, tau and eta that have been identified in mammals. 14-3-3 zeta interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Recombinant human YWHAZ, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. |
| Further Information: | Sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMDK NELVQKAKLA EQAERYDDMA ACMKSVTEQG AELSNEERNL LSVAYKNVVG ARRSSWRVVS SIEQKTEGAE KKQQMAREYR EKIETELRDI CNDVLSLLEK FLIPNASQAE SKVFYLKMKG DYYRYLAEVA AGDDKKGIVD QSQQAYQEAF EISKKEMQPT HPIRLGLALN FSVFYYEILN SPEKACSLAK TAFDEAIAEL DTLSEESYKD STLIMQLLRD NLTLWTSDTQ GDEAEAGEGG EN |
| Synonym: | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide, YWHAZ, KCIP-1, MGC111427, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide, 14-3-3 zeta, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 14 3 3 protein zeta/delta, KCIP1, Phospholipase A2, Protein kinase C inhibitor protein 1, Tyr-3/Trp-5 monooxygenase Activation protein, Zeta, Tyr3/Trp5 monooxygenase Activation protein, Zeta |
| Ascension Number: | P63104 |
| NCBI EntrezGene: | NP_663723 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
| Usage: | Research use only |
