Nrf2 Luciferase Reporter-MCF7 Cell Line
Partner: Boster Biological Technology
| Applications: | Functional Assay |
| Description: | The Nrf2 Luciferase Reporter cell line is a stably transfected MCF7 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the antioxidant response element (ARE). ARE is known to regulate expression and induction of various detoxifying enzyme genes in response to antioxidants and xenobiotics, and is primarily regulated by the Keap1-Nrf2 pathway in which induction and nuclear translocation of Nrf2 mediated by antioxidants and xenobiotics results in the binding of Nrf2 to ARE leading to the expression of defensive genes. The Nrf2 induction by dimethyl fumarate (DMF) is shown in Figure 1.� |
| Further Information: | 1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Immediately upon receipt, store in liquid nitrogen. |
| Usage: | Research use only |
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