| MW: | 59kDa |
| Purity: | >95% as determined by SDS-PAGE |
| Description: | Human CD73/NT5E protein, His tag (Animal-Free), expressed in HEK 293 Cells |
| Further Information: | CD73 (ecto-5'-nucleotidase) is a novel immunoinhibitory protein that plays a key role for tumor growth and metastasis. Its main function is to convert extracellular ATP to immunosuppressive adenosine in concert with CD39 in normal tissues to limit excessive immune response. However, tumors take advantage of the CD73-mediated adenosinergic mechanism to protect them from immune attack. In particular, inducible expression of CD73 along with other adenosinergic molecules on both cancer cells and host cells sustains immunosuppressive tumor microenvironment by affecting multiple aspects of the immune response. Owing to its multifaceted capacity to tumor promotion as an emerging immune checkpoint, CD73 is an ideal therapeutic target for cancer treatment especially in combination with conventional therapy and/or other immune checkpoint inhibitors. |
| NCBI EntrezGene: | 4907 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Lyophilized Human CD73/NT5E protein, His tag (Animal-Free)should be stored desiccated below -20 C. Upon reconstitution, the protein should be stored at 4 C between 2-7 days and for future use below -20 C. For long term storage it is recommended to add a carrier protein (0.115% HSA or BSA). Please prevent freeze-thaw cycles. |
| Usage: | Research use only |
