| MW: | 20kDa |
| Purity: | >95% as determined by SDS-PAGE |
| Description: | Human CD40/TNFRSF5 protein, His tag (Animal-Free), expressed in HEK 293 Cells |
| Further Information: | CD40 is a 48 kDa type I transmembrane protein that is constitutively expressed on hematopoietic cells such as dendritic cells, macrophages, and B cells. CD40 is a TNF receptor superfamily member expressed on both immune and non-immune cells. Interactions between B cell-expressed CD40 and its binding partner, CD40L, predominantly expressed on activated CD4+ T cells, play a critical role in promoting germinal center formation and the production of class-switched antibodies. The involvement of CD40 in chronic immune activation has resulted in CD40 being proposed as a therapeutic target for a range of chronic inflammatory diseases. CD40 antagonists are currently being explored for the treatment of autoimmune diseases and several anti-CD40 agonist mAbs have entered clinical development for oncological indications. |
| NCBI EntrezGene: | 958 |
| Shipping Conditions: | Ship on cold packs |
| Storage: | Lyophilized Human CD40/TNFRSF5 protein, His tag (Animal-Free)should be stored desiccated below -20 C. Upon reconstitution, the protein should be stored at 4 C between 2-7 days and for future use below -20 C. For long term storage it is recommended to add a carrier protein (0.114% HSA or BSA). Please prevent freeze-thaw cycles. |
| Usage: | Research use only |
