| Further Information: | The cluster of differentiation (CD) antigen CD28 is a 44 kDa, disulphide-bonded, homodimeric glycoprotein, which is a costimulatory molecule expressed on the surface of T lymphocytes and plays an important role in the activation of T cells. It mediates the co stimulation of T cells by binding to B7 molecules on APC (antigen presenting cells) . CD28 signals play a key role in many T cell processes, including cytoskeletal remodeling, production of cytokines, survival, and differentiation. Blocking CD28/B7 interactions may be useful in preventing unwanted activation in allergy and autoimmune diseases, whereas enhancing this interaction can promote tumour rejection. Thus, CD28 and its signalling pathways may prove to be useful targets in the development of new therapeutic treatments. |
