| Description: | CD117/c-Kit Protein, a tyrosine-protein kinase, acts as a cell-surface receptor for KITLG/SCF, regulating cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, function, and melanogenesis. Binding to KITLG/SCF activates diverse pathways, including PI3K/AKT, GRB2/RAS/RAF/MAPK, and STAT, resulting in downstream phosphorylation of effectors like PIK3R1, PLCG1, SH2B2/APS, CBL, and transcription factors STAT1, STAT3, STAT5A, and STAT5B. PLCG1 activation produces diacylglycerol and inositol 1,4,5-trisphosphate. CD117/c-Kit signaling undergoes regulation via protein phosphatases, receptor internalization, and degradation. Moreover, it induces phosphorylation of PTPN6/SHP-1, PTPRU, CRK, LYN, SRC, and SHC1. CD117/c-kit Protein, Mouse (495a.a, HEK293, Fc) is the recombinant mouse-derived CD117/c-kit protein, expressed by HEK293, with C-hFc labeled tag. The total length of CD117/c-kit Protein, Mouse (495a.a, HEK293, Fc) is 495 a.a., with molecular weight of ~110 kDa. |
