| Description: | Lyn Protein, a non-receptor tyrosine-protein kinase, centrally mediates signals from diverse cell surface receptors, regulating immune responses, hematopoiesis, and integrin signaling. It acts as a negative or positive regulator depending on the context, influencing B-cell responses, differentiation, and inflammatory reactions. Lyn down-regulates pathways through ITIM phosphorylation, recruiting phosphatases like PTPN6/SHP-1 and INPP5D/SHIP-1. Its kinase activity extends to various substrates, such as BTK, CD19, SYK, and KIT, showcasing its intricate involvement in diverse signaling cascades. Lyn Protein, Human (sf9, GST) is the recombinant human-derived Lyn protein, expressed by Sf9 insect cells, with N-GST labeled tag. The total length of Lyn Protein, Human (sf9, GST) is 512 a.a., with molecular weight of ~75 kDa. |
