| Description: | CD117/c-kit, a tyrosine-protein kinase receptor for KITLG/SCF, orchestrates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Upon KITLG/SCF binding, CD117 activates pathways, phosphorylating PIK3R1, PLCG1, SH2B2/APS, and CBL. It activates the AKT1 pathway through PIK3R1 phosphorylation, transmits signals via GRB2 for RAS and MAP kinase activation, and induces STAT family members (STAT1, STAT3, STAT5A, STAT5B) activation. PLCG1 produces diacylglycerol and inositol 1,4,5-trisphosphate. CD117's phosphorylation events involve PTPN6/SHP-1, PTPRU, STAT1, STAT3, STAT5A, STAT5B, PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC, and SHC1. CD117/c-kit Protein, Human (HEK293, His) is the recombinant human-derived CD117/c-kit protein, expressed by HEK293, with C-6*His labeled tag. The total length of CD117/c-kit Protein, Human (HEK293, His) is 495 a.a., with molecular weight of ~150 kDa. |
