| Description: | Leukocyte elastase inhibitor/SERPINB1 protein, a crucial neutrophil serine protease inhibitor, safeguards cells from cytoplasmic proteases during stress, regulating innate immune responses. It inhibits various neutrophil proteases, including elastase and chymotrypsin, and intracellularly blocks GZMH activity. In inflammation, SERPINB1 limits inflammatory caspases by suppressing CARD oligomerization. When secreted, SERPINB1 promotes beta-cell proliferation. Cleavage may lead to a loss of anti-protease activity and the emergence of endonuclease activity. Leukocyte elastase inhibitor/SERPINB1 Protein, Pig (His, myc) is the recombinant pig-derived Leukocyte elastase inhibitor/SERPINB1 protein, expressed by E. coli, with N-His, C-Myc labeled tag. The total length of Leukocyte elastase inhibitor/SERPINB1 Protein, Pig (His, myc) is 378 a.a., with molecular weight of ~50.0 kDa. |
