| Description: | The VEGF-A Protein, a versatile growth factor, crucially drives angiogenesis, vasculogenesis, and endothelial cell growth. Its diverse effects encompass inducing endothelial cell proliferation, promoting migration, inhibiting apoptosis, and increasing blood vessel permeability. VEGF-A achieves these functions through binding to receptors FLT1/VEGFR1, KDR/VEGFR2, and heparan sulfate/heparin. Interaction with NRP1 initiates a signaling pathway essential for motor neuron axon guidance and cell body migration in embryonic development. Additionally, VEGF-A binds to the DEAR/FBXW7-AS1 receptor, expanding its regulatory roles. The homodimeric structure, linked by disulfide bonds, and potential heterodimer formation with PGF highlight the intricate molecular relationships underlying VEGF-A's multifaceted functions in vascular processes and embryonic development. VEGF-A Protein, Pig (His) is the recombinant pig-derived VEGF-A protein, expressed by E. coli, with N-6*His labeled tag. The total length of VEGF-A Protein, Pig (His) is 164 a.a., with homodimer molecular weight of ~23.2 kDa. |
