| Description: | Protein E6, HPV16, serves as a crucial oncoprotein by forming a complex with UBE3A/E6-AP ubiquitin-protein ligase. This complex leads to the degradation of tumor suppressors TP53 and TP73 by the 26S proteasome, inducing DNA damage and chromosomal instabilities. E6's multifaceted actions include directing proteasomal degradation of substrates like DLG1 and NFX1, inhibiting apoptosis through BAK1, FADD, and procaspase 8 degradation, and interfering with immune response by interacting with IRF3 and TYK2. These interactions underscore E6's pivotal role in cellular transformation and evasion of host defense mechanisms. Protein E6, HPV16 (His) is the recombinant Virus-derived protein E6, HPV16, expressed by E. coli, with N-6*His labeled tag. The total length of Protein E6, HPV16 (His) is 158 a.a., the molecular weight are 22 KDa (monomer), 44 KDa (dimer), whiel dimers are generally formed. |
