| Description: | SLC31A1 Protein, a vital uniporter, transports copper(1+) from the extracellular space into the cytoplasm with remarkable specificity, directly delivering it to chaperones like ATOX1. This process tightly regulates intracellular copper(1+) levels and potentially participates in intestinal copper absorption. The sodium-independent, high-affinity, saturable mechanism extends to silver(1+) and platinum-containing chemotherapeutic agents, impacting therapeutic responses. Acting as a redox sensor, SLC31A1 promotes angiogenesis by transmitting VEGF-induced ROS signals through sulfenylation at Cys-189, forming a disulfide bond with KDR. This multifaceted protein also mobilizes copper(1+) out of endosomes, contributing to cellular copper homeostasis. SLC31A1 Protein, Human (Cell-Free, His-SUMO) is the recombinant human-derived SLC31A1 protein, expressed by E. coli Cell-free, with N-SUMO, N-6*His labeled tag. The total length of SLC31A1 Protein, Human (Cell-Free, His-SUMO) is 190 a.a., the molecular weight are 40 KDa (monomer), 80 KDa (dimer), whiel dimers are generally formed. |
