Description: | Staphopain B, a cysteine protease, crucially undermines host immunity by degrading elastin, fibrogen, fibronectin, and kininogen. It hinders opsonized S. aureus phagocytosis, inducing death in neutrophils and monocytes through proteolytic activity. Staphopain B downregulates CD31 on neutrophils and cleaves galectin-3/LGALS3, limiting its neutrophil-activating capabilities. Staphostatin B (SspC) regulates Staphopain B's premature activation, likely protecting staphylococcal cytoplasmic proteins from degradation by SspB. Staphopain B Protein, S. aureus (GST) is the recombinant Staphylococcus aureus-derived Staphopain B protein, expressed by E. coli, with N-GST labeled tag. The total length of Staphopain B Protein, S. aureus (GST) is 174 a.a., with molecular weight of ~46.9 kDa. |