| Description: | PNPLA2 protein, a key participant in lipid metabolism, serves as the catalyst for the initial step in triglyceride hydrolysis within adipocyte and non-adipocyte lipid droplets. Demonstrating a pronounced preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone, PNPLA2 operates in coordination with LIPE/HLS and DGAT2 in the lipolytic cascade. Beyond its primary function, PNPLA2 exhibits additional activities, including acylglycerol transacylase and phospholipase A2 functions, showcasing its versatility in lipid-related processes. Moreover, it plays a role in modulating adiposome size and is implicated in the degradation of adiposomes. Furthermore, PNPLA2 contributes to energy homeostasis and potentially responds to starvation, enhancing triglyceride hydrolysis to provide free fatty acids for oxidation in energy-depleted conditions. Additionally, PNPLA2 catalyzes the formation of ester bonds, generating fatty acid esters of hydroxy fatty acids (FAHFAs) in adipocytes, thereby expanding its multifaceted involvement in lipid homeostasis. PNPLA2 Protein, Human (His-SUMO) is the recombinant human-derived PNPLA2 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of PNPLA2 Protein, Human (His-SUMO) is 504 a.a., with molecular weight of ~71.3 kDa. |
