| Description: | MUSK Protein, a receptor tyrosine kinase, crucially orchestrates neuromuscular junction (NMJ) formation. Activated by the AGRIN-LRP4 complex, MUSK regulates NMJ through gene expression, actin cytoskeleton reorganization, and acetylcholine receptor (AChR) clustering. ABL1 and Src kinases modulate AChR phosphorylation, mediated by MUSK. MUSK forms a complex with DVL1 and PAK1, crucial for AChR regulation. Additionally, MUSK activates Rho GTPases via FNTA, influencing actin cytoskeleton and gene expression. Downstream, DNAJA3 responds to MUSK signaling. MUSK's role extends to the central nervous system, impacting cholinergic responses, synaptic plasticity, and memory formation. MUSK Protein, Mouse (Myc, His-SUMO) is the recombinant mouse-derived MUSK protein, expressed by E. coli, with C-Myc, N-SUMO, N-10*His labeled tag. The total length of MUSK Protein, Mouse (Myc, His-SUMO) is 473 a.a., with molecular weight of ~69.3 kDa. |
