| Description: | SPARC protein, crucial for lipid transport, participates in plasma lipoprotein production, conversion, and clearance. It interacts with diverse particles, showing a preference for HDL, and binds to cellular receptors like LDLR and VLDLR, facilitating APOE-containing lipoprotein uptake. SPARC, with heparin-binding activity, interacts with heparan-sulfate proteoglycans, aiding in lipoprotein capture and receptor-mediated uptake. Moreover, SPARC plays a role in diverse physiological processes by interacting with APP, MAPT, MAP2, secreted SORL1, and PMEL. SPARC Protein, Human (HEK293, His) is the recombinant human-derived SPARC protein, expressed by HEK293, with C-6*His labeled tag. The total length of SPARC Protein, Human (HEK293, His) is 286 a.a., with molecular weight of ~38.0 kDa. |
