| Description: | OPRD1 Protein, a G-protein coupled receptor for enkephalins and opioids, undergoes ligand-induced conformational changes, activating signaling via G proteins and inhibiting adenylate cyclase. Additionally, it reduces neurotransmitter release by affecting ion currents. Crucial for pain perception and opiate-mediated analgesia, OPRD1 forms homooligomers, heterodimerizes with OPRM1, and interacts with GPRASP1 and RTP4 to regulate cell surface localization. These interactions illustrate the intricate regulatory mechanisms through which OPRD1 modulates opioid signaling and analgesic responses. OPRD1 Protein, Human (Cell-Free, His) is the recombinant human-derived OPRD1 protein, expressed by E. coli Cell-free, with N-10*His labeled tag. The total length of OPRD1 Protein, Human (Cell-Free, His) is 372 a.a., with molecular weight of 41.9 kDa. |
