| Description: | NLRP3 Protein serves as the sensor in the NLRP3 inflammasome, activating in response to membrane defects. It forms a complex with CASP1 and PYCARD/ASC, promoting IL1B, IL18, and GSDMD release, inducing pyroptosis. Activation stimuli include ATP, nigericin, reactive oxygen species, and various particles. NEK7 unlocks NLRP3, allowing relocalization to the trans-Golgi network and inflammasome formation. NLRP3 also regulates T helper 2 cell differentiation, influencing asthma and tumor growth. It binds to specific DNA sequences, participating in transcription processes. NLRP3 Protein, Human (GST) is the recombinant human-derived NLRP3 protein, expressed by E. coli, with N-GST labeled tag. The total length of NLRP3 Protein, Human (GST) is 574 a.a., with molecular weight of 93.20 kDa. |
