| Description: | BMP-13/GDF-6 Protein, a pivotal growth factor, regulates retinal processes, apoptosis, and dorsal-ventral positional information, crucial for retinotectal map formation. In skeletal development, it is indispensable for bones and joints in limbs, skull, digits, and axial skeleton, shaping species-specific skeletal evolution. BMP-13/GDF-6 positively regulates chondrogenic tissue differentiation via BMPR1A, BMPR1B, BMPR2, and ACVR2A, activating the SMAD1-SMAD5-SMAD8 complex, inhibited by NOG. It induces adipogenesis from mesenchymal stem cells through BMPR1A, BMPR2, and ACVR2A, activating SMAD1-SMAD5-SMAD8 and MAPK14/p38 via homodimerization with disulfide-linked structures. Animal-Free BMP-13/GDF-6 Protein, Human (His) is the recombinant human-derived animal-FreeBMP-13/GDF-6 protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free BMP-13/GDF-6 Protein, Human (His) is 120 a.a., with molecular weight of ~14.50 kDa. |
