Description: | Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 ?M), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 ?M) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 ?M) and D4 (EC50=2 ?M) receptor. |