Data Sheet

MSDS

Crizotinib [CAS 877399-52-5]

CAS No:	877399-52-5
Applications:	Cancer-Kinase/protease
MW:	450.34
Formula:	C₂₁H₂₂Cl₂FN₅O
SMILES:	ClC1=C(F)C=CC(Cl)=C1[C@H](OC2=CC(C3=CN(N=C3)C4CCNCC4)=CN=C2N)C
Purity:	99.97
Description:	Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition[1][2][3].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only