Data Sheet

MSDS

T6167923 [CAS 2437475-16-4]

CAS No:	2437475-16-4
Applications:	Neuroscience-Neuromodulation
MW:	458.39
Formula:	C₁₇H₂₀BrN₃O₃S₂
SMILES:	BrC1=CC(S(=O)(N2CCN(C(N[C@H](C3=CC=CS3)C)=O)CC2)=O)=CC=C1
Purity:	99.08
Description:	T6167923 is a selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-?B driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with IC50s of 2.7 ??M, 2.9 ?M, 2.66 ?M and 2.66 ?M for IFN-?, IL-1?, IL-6 and TNF-?, respectively[1][2].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only