Data Sheet

MSDS

Purvalanol B [CAS 212844-54-7]

CAS No:	212844-54-7
Applications:	Cancer-Kinase/protease
MW:	432.90
Formula:	C₂₀H₂₅ClN₆O₃
SMILES:	O=C(O)C1=CC=C(NC2=C3N=CN(C(C)C)C3=NC(N[C@@H](CO)C(C)C)=N2)C=C1Cl
Purity:	97.0
Description:	Purvalanol B (NG 95) is a potent, selective, reversible and ATP-competitive inhibitor CDK, with IC50s of 6 nM, 6 nM, 9 nM, 6 nM for cdc2-cyclin B, CDK2-cyclin A, CDK2-cyclin E and CDK5-p35, respectively. Purvalanol B shows selectivity for CDK over a range of other protein kinases (IC50>1000 nM). Purvalanol B inhibits the growth a chloroquine-resistant strain of P. falciparum[1][1].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only