Data Sheet

MSDS

PF-04995274 [CAS 1331782-27-4]

CAS No:	1331782-27-4
Applications:	Neuroscience-Neurodegeneration
MW:	432.51
Formula:	C₂₃H₃₂N₂O₆
SMILES:	OC1(CN2CCC(COC3=NOC4=CC=CC(O[C@H]5COCC5)=C34)CC2)CCOCC1
Purity:	99.95
Description:	PF-04995274 is a potent, high-affinity, orally active and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 has an EC50 range of 0.26-0.47 nM for human 5-HT4A/4B/4D/4E (Ki range of 0.15-0.46 nM), and has an EC50 range of 0.59-0.65 nM for rat 5-HT4S/4L/4E (Ki of 0.30 nM for rat 5-HT4S). PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease[1][2][3].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only