Data Sheet

MSDS

BI-9627 [CAS 1204329-34-9]

CAS No:	1204329-34-9
Applications:	Neuroscience-Neuromodulation
MW:	356.34
Formula:	C₁₆H₁₉F₃N₄O₂
SMILES:	NC(NC(C1=CC=C(C2CCN(C(C)=O)CC2)C(C(F)(F)F)=C1)=O)=N
Purity:	99.0
Description:	BI-9627 is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury[1].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only