Data Sheet

MSDS

PF-915275 [CAS 857290-04-1] (10mM in DMSO)

CAS No:	857290-04-1
Applications:	Metabolism-sugar/lipid metabolism
MW:	350.39
Formula:	C₁₈H₁₄N₄O₂S
SMILES:	N#CC1=CC=C(C2=CC=C(S(NC3=NC(N)=CC=C3)(=O)=O)C=C2)C=C1
Purity:	99.59
Description:	PF-915275 is a potent, selective and orally active human 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) inhibitor with a Ki of 2.3 nM and an EC50 of 15 nM (in HEK293 cells). The dose-dependent effect of PF-915275 on conversion of cortisone to cortisol in primary human and monkey hepatocytes, with an EC50 of 20 and 100 nM, respectively[1][2][3].
Shipping Conditions:	Ship on cold packs
Usage:	Research Use Only