Data Sheet

MSDS

Pexidartinib (hydrochloride) [CAS 2040295-03-0]

CAS No:	2040295-03-0
Applications:	Cancer-Kinase/protease
MW:	454.28
Formula:	C₂₀H₁₆Cl₂F₃N₅
SMILES:	FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=N1)(F)F.Cl
Purity:	99.89
Description:	Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib hydrochloride induces cell apoptosis and has anti-cancer activity[1].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only