Data Sheet

MSDS

LYP-IN-4

MW:	593.00
Formula:	C₂₉H₂₁ClN₂O₈S
SMILES:	O=C(O)C1=CC2=CC(N(S(=O)(C(C=C3)=CC(Cl)=C3[N+]([O-])=O)=O)CC4=CC=C(C=C4)C5=CC=C(C=C5)OC)=CC=C2O1
Purity:	98.09
Description:	LYP-IN-4 (compound D14) is a reversible and selective inhibitor of lymphotyrosine phosphatase (LYP) (Ki=1.34 ?M, IC50=3.52?M). LYP-IN-4 inhibits LYP to regulate TCR signaling, up-regulates PD-1/PD-L1 expression, and enhance anti-tumor immunity. LYP-IN-4 activates T cells and inhibits M2 macrophage polarization, inhibits tumor growth in MC38 isogenic mouse models.
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only