Description: | MRK-898 is an orally active GABA(A) receptor modulator. MRK-898 binds to ?1, ?2, ?3 or ?5 subunit of GABA(A) receptor with Ki values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. However, ?1-containing GABA(A) receptors are identified as the sedative and ?2- and/or ?3-containing receptors as the anxiolytic subtype(s)[1]. |