Data Sheet

MSDS

NX-2127 [CAS 2416131-46-7]

CAS No:	2416131-46-7
Applications:	Cancer-Kinase/protease
MW:	719.83
Formula:	C₃₉H₄₅N₉O₅
SMILES:	O=C1C2=CC(N3C[C@H](CN4CCC(C5=CC=C(C=C5)NC6=C(N=CC(N7CCCCC7)=N6)C(N)=O)CC4)CC3)=CC=C2C(N1C8C(NC(CC8)=O)=O)=O
Purity:	99.72
Description:	NX-2127 is an orally and potent BTK inhibitor, inducing degradation of the mutated BTKC481S in cells. NX-2127 inhibits proliferation of BTKC481S mutant TMD8 cells, more effectively than Ibrutinib (HY-10997). NX-2127 catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) with of 25 nM and 54 nM, respectively. NX-2127 stimulates T cell activation and increases IL-2 production in primary human T Cells[1][2].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only