Data Sheet

MSDS

MSA-2 [CAS 129425-81-6] (10mM in DMSO)

CAS No:	129425-81-6
Applications:	COVID-19-immunoregulation
MW:	294.32
Formula:	C₁₄H₁₄O₅S
SMILES:	O=C(C1=CC(C(S1)=C2)=CC(OC)=C2OC)CCC(O)=O
Purity:	99.64
Description:	MSA-2, a potent and orally available non-nucleotide STING agonist, is bound to STING as a noncovalent dimer with nanomolar affinity. MSA-2 shows EC50s of 8.3 and 24 ?M for human STING isoforms WT and HAQ, respectively. MSA-2 stimulates interferon-? secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models[1][2].
Shipping Conditions:	Ship on cold packs
Usage:	Research Use Only