Data Sheet

MSDS

ZX-29 [CAS 2254805-62-2]

CAS No:	2254805-62-2
Applications:	Cancer-Kinase/protease
MW:	518.03
Formula:	C₂₃H₂₈ClN₇O₃S
SMILES:	CS(=O)(NC1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCN(C)CC4)C=C3OC)=NC=C2Cl)=O
Purity:	99.52
Description:	ZX-29 is a potent and selective ALK inhibitor with an IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively. ZX-29 is inactive against EGFR. ZX-29 induces apoptosis by inducing endoplasmic reticulum (ER) stress and overcomes cell resistance caused by an ALK mutation. ZX-29 also induces protective autophagy and has antitumor effect[1].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only