Data Sheet

MSDS

Cabozantinib [CAS 849217-68-1] (10mM in DMSO)

CAS No:	849217-68-1
Applications:	Cancer-Kinase/protease
MW:	501.51
Formula:	C₂₈H₂₄FN₃O₅
SMILES:	O=C(C1(CC1)C(NC2=CC=C(F)C=C2)=O)NC3=CC=C(C=C3)OC4=C5C=C(OC)C(OC)=CC5=NC=C4
Purity:	99.96
Description:	Cabozantinib is a potent and orally active inhibitor of VEGFR2 and MET, with IC50 values of 0.035, and 1.3 nM, respectively. Cabozantinib displays strong inhibition of KIT, RET, AXL, TIE2, and FLT3 (IC50=4.6, 5.2, 7, 14.3, and 11.3 nM, respectively). Cabozantinib shows antiangiogenic activity. Cabozantinib disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis[1][2].
Shipping Conditions:	Ship on cold packs
Usage:	Research Use Only