PF-5006739 [CAS 1293395-67-1]
Partner: MedChemexpress LLC
| CAS No: | 1293395-67-1 |
| Applications: | Neuroscience-Neuromodulation |
| MW: | 419.45 |
| Formula: | C22H22FN7O |
| SMILES: | NC1=NC=CC(C2=C(C3=CC=C(F)C=C3)N=CN2C4CCN(CC5=NOC=C5)CC4)=N1 |
| Purity: | 99.56 |
| Description: | PF-5006739 is a potent and selective inhibitor of CK1?/? with IC50s of 3.9 nM and 17.0 nM, respectively. PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1?/? and high kinome selectivity. PF-5006739 attenuats opioid agent-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner[1]. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity[2]. |
| Shipping Conditions: | Ship at ambient |
| Usage: | Research Use Only |
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