Data Sheet

MSDS

NB-360 [CAS 1262857-73-7]

CAS No:	1262857-73-7
Applications:	Neuroscience-Neurodegeneration
MW:	449.40
Formula:	C₂₁H₁₉F₄N₅O₂
SMILES:	O=C(C1=NC=C(C#N)C=C1C)NC2=CC=C(F)C([C@]3(C)CO[C@](C(F)(F)F)(C)C(N)=N3)=C2
Purity:	99.22
Description:	NB-360 is a potent, brain penetrable, and orally bioavailable dual BACE1/BACE2 inhibitor (IC50: mouse and human BACE1=5 nM; BACE2=6 nM). NB-360 shows a superior pharmacological profile and robust reduction of amyloid-? and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB-360 can completely block the progression of A? deposition in the brains of APP transgenic mice. NB-360 shows excellent selectivity over the related aspartyl proteases pepsin, cathepsin D and cathepsin E[1][2].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only