GNE-0439 [CAS 1241902-40-8]
Partner: MedChemexpress LLC
| CAS No: | 1241902-40-8 |
| Applications: | Neuroscience-Neuromodulation |
| MW: | 345.48 |
| Formula: | C21H31NO3 |
| SMILES: | CC(C)[C@@H](C(O)=O)NC(C1=CC=C(C2CCC(CCC)CC2)C=C1)=O |
| Purity: | 99.80 |
| Description: | GNE-0439 is a novel Nav1.7-selective inhibitor with IC50 of 0.34 uM and inhibits Nav1.5 with an IC50 of 38.3 ?M. GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays. GNE-0439 possesses a carboxylic acid group, binds outside of the channel pore, and is unique compared with known selective VSD4 binders[1]. |
| Shipping Conditions: | Ship at ambient |
| Usage: | Research Use Only |
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