Description: | (-)-Indolactam V is a PKC activator, with Kis of 3.36 nM, 1.03 ?M for ?-CRD2 (PKC? surrogate peptide), ?-CRD2 (PKC? surrogate peptide), and Kds of 5.5 nM (?-C1B), 7.7 nM (?-C1B), 8.3 nM (?-C1B), 18.9 nM (?-C1A-long), 20.8 nM (?-C1A-long), 137 nM (?-C1B), 138 nM (?-C1A), 213 nM (?-C1B), and has antitumor activity. |