Data Sheet

MSDS

BMS-599626 (Hydrochloride) [CAS 873837-23-1]

CAS No:	873837-23-1
Applications:	Cancer-Kinase/protease
MW:	567.01
Formula:	C₂₇H₂₈ClFN₈O₃
SMILES:	O=C(OC[C@H]1NCCOC1)NC2=CN(C3=C2C)N=CN=C3NC4=CC5=C(C=C4)N(CC6=CC(F)=CC=C6)N=C5.Cl
Purity:	99.68
Description:	BMS-599626 Hydrochloride (AC480 Hydrochloride) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC50s of 20 and 30 nM, respectively. BMS-599626 Hydrochloride displays ~8-fold less potent to HER4 (IC50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. BMS-599626 Hydrochloride inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy[1][2].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only