Data Sheet

MSDS

GW406108X [CAS 1644443-92-4]

CAS No:	1644443-92-4
Applications:	COVID-19-immunoregulation
MW:	400.21
Formula:	C₂₀H₁₁Cl₂NO₄
SMILES:	O=C1NC2=C(C=C(C(C3=CC=CO3)=O)C=C2)/C1=C/C4=CC(Cl)=C(O)C(Cl)=C4
Purity:	98.0
Description:	GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X, a potent autophagy inhibitor, shows ATP competitive inhibition against ULK1 with a pIC50 of 6.37 (427 nM). GW406108X inhibits ULK1 kinase activity and blocks autophagic flux, without affecting the upstream signaling kinases mTORC1 and AMPK[1][2].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only