Data Sheet

MSDS

SPP-86 [CAS 1357349-91-7]

CAS No:	1357349-91-7
Applications:	Neuroscience-Neuromodulation
MW:	277.32
Formula:	C₁₆H₁₅N₅
SMILES:	CC(C)N1C2=NC=NC(N)=C2C(C#CC3=CC=CC=C3)=N1
Purity:	99.62
Description:	SPP-86 is a potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM. SPP-86 inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling, also inhibits RET-induced estrogen receptor? (ER?) phosphorylation in MCF7 cells[1]. SPP-86 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only